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Blog dedicado a temas de interés relacionados con enfermedades del aparato osteomuscular
viernes, 22 de abril de 2011
lunes, 18 de abril de 2011
Introducción al aparato osteomuscular
Es el primum movens del organismo, comprende huesos, articulaciones, ligamentos, músculos, entesos. También se le conoce como aparato osteomusculoarticular.
miércoles, 13 de abril de 2011
IL-1 y diacereína
Artículo publicado en el periódico médico Medicina de Posgrado
http://issuu.com/alejandromeloflorian/docs/il1_en_oa_med_posg_2011_apr
http://issuu.com/alejandromeloflorian/docs/il1_en_oa_med_posg_2011_apr
martes, 12 de abril de 2011
IL-1 in osteoarthritis
Given the high and rising figures of people with osteoarthritis, knowledge of new factors defining course and evolution of the disease are important, when considering new pharmacological targets.
IL-1 is a very important cytokine in the early steps of osteoarthritis, giving the high sensitivity of the chondrocytes to this cytokine, and it can be considered the bridge permiting the dialogue between the different structures of the articulation, in such a way that the cartilage is not the only tissue affected in OA.
IL-1 increases the destruction of the extracellular matrix of the cartilage increasing the collagenolytic activity of metalloproteases, increasing activity of nytric oxide ON, wich can induce apoptosis of chondrocytes. Interestingly, IL-1 further induces changes in the homeostasis of the cartilage, lessening activity of growth factors, such as TGF-beta.
IL-1 is a very important cytokine in the early steps of osteoarthritis, giving the high sensitivity of the chondrocytes to this cytokine, and it can be considered the bridge permiting the dialogue between the different structures of the articulation, in such a way that the cartilage is not the only tissue affected in OA.
IL-1 increases the destruction of the extracellular matrix of the cartilage increasing the collagenolytic activity of metalloproteases, increasing activity of nytric oxide ON, wich can induce apoptosis of chondrocytes. Interestingly, IL-1 further induces changes in the homeostasis of the cartilage, lessening activity of growth factors, such as TGF-beta.
Nociones de metabolismo óseo
El conocimiento en mayor detalle de la biología del hueso permite entender el tejido óseo como uno dinámico, en donde hay componentes celulares y moleculares de la remodelación y crecimiento del hueso. Esto permite entender las funciones del hueso, el concepto de masa y fragilidad ósea.
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